ASCP Specialist in Hematology (SH) Practice Exam 2025 - Free Hematology Specialist Practice Questions and Study Guide

In cases of hemolytic anemia, bilirubin levels are typically elevated due to the increased breakdown of red blood cells. Hemolytic anemia involves the destruction of red blood cells at a rate that surpasses the body’s ability to produce new ones. As these cells are destroyed, hemoglobin is released and subsequently broken down into biliverdin, which is converted into unconjugated bilirubin. This increase in unconjugated bilirubin can lead to jaundice, as the liver's conjugation and excretion processes may become overwhelmed.

In contrast, hematocrit may not be elevated in hemolytic anemia; it often decreases due to the loss of red blood cells. While platelet count and white blood cell count can vary in hemolytic anemia, they are not consistently elevated as a direct result of the condition. Therefore, the elevation of bilirubin serves as a significant indicator of hemolysis occurring in the body, making it the correct parameter associated with hemolytic anemia.